Kinetolab

publications

Here we share our own original research work in collaboration with other scientists, where you can gain insight into our experience, expertise, and recognition in the field of research.

PDTX

Evolving Acquired Vemurafenib Resistance in a BRAF V600E Mutant Melanoma PDTX Model to Reveal New Potential Targets.

Tóvári J, Vári-Mező D, Surguta SE, Ladányi A, Kigyós A, Cserepes M.

Cells. 2023, 12(14), 1919.

PEPTIDE-DRUG CONJUGATES

Optimizing the Enzymatic Release of MMAE from isoDGR-based Small Molecule Drug Conjugate by Incorporation of a GPLG-PABC Enzymatically Cleavable Linker.

Zambra M, Ranđelović I, Talarico F, Borbély A, Svajda L, Tóvári J, Mező G, Bodero L, Colombo S, Arrigoni F, Fasola E, Gazzola S, Piarulli U.

Front Pharmacol. 2023, 14:1215694.

KRAS TARGETING
- FRAGMENT SCREENING

Activation-Free Sulfonyl Fluoride Probes for Fragment Screening.

Petri L, Ábrányi-Balogh P, Csorba N, Keeley A, Simon J, Ranđelović I, Tóvári J, Schlosser G, Szabó D, Drahos L, Keserű GM.

Molecules. 2023, 28(7):3042.

KRAS targeting

Covalent fragment mapping of KRasG12C revealed novel chemotypes with in vivo potency.

Orgován Z, Péczka N, Petri L, Ábrányi-Balogh P, Ranđelović I, Tóth S, Szakács G, Nyíri K, Vértessy B, Pálfy G, Vida I, Perczel A, Tóvári J and Keserű GM.

Eur J Med Chem. 2023, 115212.

PEPTIDE-DRUG CONJUGATES

Targeting the Gastrin-Releasing Peptide Receptor (GRP-R) in Cancer Therapy: Development of Bombesin-Based Peptide–Drug Conjugates.

Gomena L, Vári B, Oláh-Szabó R, Biri-Kovács B, Bősze S, Borbély A, Soós A, Ranđelović I, Tóvári J and Mező G.

Int. J. Mol. Sci. 2023, 24(4), 3400.

ALZHEIMER’S DISEASE INHIBITORS

Dual Inhibitors of AChE and BACE-1 for Reducing Aβ in Alzheimer’s Disease: From In Silico to In Vivo.

Stern N, Gacs A, Tátrai E, Flachner B, Hajdú I, Dobi K, Bágyi I, Dormán G, Lőrincz Z, Cseh S, Kígyós A, Tóvári J, Goldblum A.

Int J Mol Sci. 2022 Oct 28;23(21):13098.

PARKINSON’S DISEASE VACCINE

A Novel C-Type Lectin Receptor-Targeted α-Synuclein-Based Parkinson Vaccine Induces Potent Immune Responses and Therapeutic Efficacy in Mice.

Schmidhuber S, Scheiblhofer S, Weiss R, Cserepes M, Tóvári J, Gadermaier G, Bezard E, De Giorgi F, Ichas F, Strunk D, Mandler M.

Vaccines (Basel). 2022 Aug 30;10(9):1432.

KRAS targeting

Allele-specific inhibitors of mutant KRAS are in the focus of RASopathy consortium.

Nyíri K, Koppány G, Pálfy G, Vida I, Tóth S, Orgován Z, Ranđelović I, Baranyi M, Molnár E, Keserû MG, Tóvári J, Perczel A, Vértessy BG, Tímár J.

Magy Onkol. 2019; 9;63(4):310-323.

FAK INHIBITOR

The FAK inhibitor BI 853520 inhibits spheroid formation and orthotopic tumor growth in malignant pleural mesothelioma.

Laszlo V, Valko Z, Ozsvar J, Kovacs I, Garay T, Hoda MA, Klikovits T, Stockhammer P, Aigner C, Gröger M, Klepetko W, Berger W, Grusch M, Tovari J, Waizenegger IC, Dome B, Hegedus B.

J Mol Med (Berl). 2019; 97(2):231-242.

ANGIOGENESIS INHIBITION

Nintedanib Is Active in Malignant Pleural Mesothelioma Cell Models and Inhibits Angiogenesis and Tumor Growth In Vivo.

Laszlo V, Valko Z, Kovacs I, Ozsvar J, Hoda MA, Klikovits T, Lakatos D, Czirok A, Garay T, Stiglbauer A, Helbich TH, Gröger M, Tovari J, Klepetko W, Pirker C, Grusch M, Berger W, Hilberg F, Hegedus B, Dome B.

Clin Cancer Res. 2018; 24(15):3729-3740.