We propose a microchannel-based device that is able to capture a specific cell type using combined markers for the analysis of cellular content of samples. The device is essentially a set of narrow channels through which the cells can be pumped through. Some areas on channel wall are functionalized with a combination of receptors that are binding to their corresponding markers on the cell’s surface. The flow conditions and the channel dimensions are optimized on the way that if more than one marker is present on the cell surface then the cell gets stuck in the channel. The number of such stuck channels can be determined by optical or electrical means, e.g. using the change in the impedance of the channel.