Published a study about a gluing docking method for finding small molecules that bind to both the GAP and the mutated KRAS molecules
07/03/2024 Publications Published a study about a gluing docking method for finding small molecules that bind to both the GAP and the mutated KRAS molecules KINETO Lab proudly announcing that research in the frame of KRAS consortium about new approach for finding small molecules that can be used to attach GAP molecules to RAS proteins […]
Published a new study on targeting KRAS with combination of KRAS-G12C and Farnesyl-transferase inhibitors in British Journal of Cancer
10/02/2024 Publications Published a new study on targeting KRAS with combination of KRAS-G12C and Farnesyl-transferase inhibitors in British Journal of Cancer We proudly announce that it is publiched the research of KINETO Lab and collaborators on targeting KRAS with combination of KRAS-G12C and Farnesyl-transferase inhibitors, in British Journal of Cancer. Our findings warrant the clinical […]
Announce of the first publication using our Patient-Derived Tumor Xenograft (PDTX) models in Cells journal
27/07/2023 Publications Announce of the first publication using our Patient-Derived Tumor Xenograft (PDTX) models in Cells journal We are pleased to announce that the first paper related to study of our Patient-Derived Tumor Xenograft (PDTX) models, entitled „Evolving Acquired Vemurafenib Resistance in a BRAF V600E Mutant Melanoma PDTX Model to Reveal New Potential Targets” is […]
Publication in Frontiers in Pharmacology on Optimizing the Enzymatic Release of MMAE from isoDGR-based SMDC by Incorporation of a GPLG-PABC Enzymatically Cleavable Linker
13/07/2023 Publications Publication in Frontiers in Pharmacology on Optimizing the Enzymatic Release of MMAE from isoDGR-based SMDC by Incorporation of a GPLG-PABC Enzymatically Cleavable Linker As a member of Magicbullet::Reloaded Consortium, KINETO Lab took a big part in the study where the use of GPLG-PABC linker in a Small Molecule Drug Conjugates (SMDC), as an […]
Published a study about Activation-Free Sulfonyl Fluoride Probes for Fragment Screening
30/03/2023 Publications Published a study about Activation-Free Sulfonyl Fluoride Probes for Fragment Screening In Molecules journal was published the research about synthesis and characterization of a small sulfonyl fluoride library for tagging tractable targets at nucleophilic residues. Based on the results, it was propose that coupling diverse fragments to this warhead would result in a […]
Publication in European Journal of Medicinal Chemistry on covalent fragment mapping of KRasG12C which reveals novel chemotypes with in vivo potency
20/02/2023 Publications Publication in European Journal of Medicinal Chemistry on covalent fragment mapping of KRasG12C which reveals novel chemotypes with in vivo potency As a member of KRAS Consortium, KINETO Lab was big part of the research to identify fragments as suitable starting points targeting KRasG12C, pre-selected in covalent fragment screening of the electrophilic fragment […]
Published a new study on Targeting the Gastrin-Releasing Peptide Receptor (GRP-R) in Cancer Therapy
10/02/2023 Publications Published a new study on Targeting the Gastrin-Releasing Peptide Receptor (GRP-R) in Cancer Therapy KINETO Lab took a part in development of Bombesin-Based Peptide–Drug Conjugates, acting as drug delivery systems to safely reach the tumour environment. Two of bioconjugates revealed remarkable anti-proliferative activity, an efficient uptake by all three tested human breast and […]
Published a new study on Dual Inhibitors of AChE and BACE-1 for Reducing Aβ in Alzheimer’s Disease: From In Silico to In Vivo
07/11/2022 Publications Published a new study on Dual Inhibitors of AChE and BACE-1 for Reducing Aβ in Alzheimer’s Disease: From In Silico to In Vivo By applying the computational methods in order to search for dual-inhibitors that could prevent the production of hazardous Aβ42 peptides and avoid their aggregation, it was developed molecules which inhibit AChE and BACE-1 […]
Announced publication in Vaccines (Basel) on A Novel C-Type Lectin Receptor-Targeted α-Synuclein-Based Parkinson Vaccine
07/09/2022 Publications Announced publication in Vaccines (Basel) on A Novel C-Type Lectin Receptor-Targeted α-Synuclein-Based Parkinson Vaccine We are pleased to announce that our newest paper in the journal Vaccines (Basel) is now published online. This study provides proof-of-concept for the efficacy of the ‘Win the Skin Immune System Trick’ (WISIT) vaccine technology platform, which induces […]