Kinetolab

Publication in Frontiers in Pharmacology on Optimizing the Enzymatic Release of MMAE from isoDGR-based SMDC by Incorporation of a GPLG-PABC Enzymatically Cleavable Linker

13/07/2023 Publications Publication in Frontiers in Pharmacology on Optimizing the Enzymatic Release of MMAE from isoDGR-based SMDC by Incorporation of a GPLG-PABC Enzymatically Cleavable Linker As a member of Magicbullet::Reloaded Consortium, KINETO Lab took a big part in the study where the use of GPLG-PABC linker in a Small Molecule Drug Conjugates (SMDC), as an […]

Published a study about Activation-Free Sulfonyl Fluoride Probes for Fragment Screening

30/03/2023 Publications Published a study about Activation-Free Sulfonyl Fluoride Probes for Fragment Screening In Molecules journal was published the research about synthesis and characterization of a small sulfonyl fluoride library for tagging tractable targets at nucleophilic residues. Based on the results, it was propose that coupling diverse fragments to this warhead would result in a […]

Publication in European Journal of Medicinal Chemistry on covalent fragment mapping of KRasG12C which reveals novel chemotypes with in vivo potency

20/02/2023 Publications Publication in European Journal of Medicinal Chemistry on covalent fragment mapping of KRasG12C which reveals novel chemotypes with in vivo potency As a member of KRAS Consortium, KINETO Lab was big part of the research to identify fragments as suitable starting points targeting KRasG12C, pre-selected in covalent fragment screening of the electrophilic fragment […]

Published a new study on Targeting the Gastrin-Releasing Peptide Receptor (GRP-R) in Cancer Therapy

10/02/2023 Publications Published a new study on Targeting the Gastrin-Releasing Peptide Receptor (GRP-R) in Cancer Therapy KINETO Lab took a part in development of Bombesin-Based Peptide–Drug Conjugates, acting as drug delivery systems to safely reach the tumour environment. Two of bioconjugates revealed remarkable anti-proliferative activity, an efficient uptake by all three tested human breast and […]

Published a new study on Dual Inhibitors of AChE and BACE-1 for Reducing Aβ in Alzheimer’s Disease: From In Silico to In Vivo

07/11/2022 Publications Published a new study on Dual Inhibitors of AChE and BACE-1 for Reducing Aβ in Alzheimer’s Disease: From In Silico to In Vivo By applying the computational methods in order to search for dual-inhibitors that could prevent the production of hazardous Aβ42 peptides and avoid their aggregation, it was developed molecules which inhibit AChE and BACE-1 […]

Announced publication in Vaccines (Basel) on A Novel C-Type Lectin Receptor-Targeted α-Synuclein-Based Parkinson Vaccine

07/09/2022 Publications Announced publication in Vaccines (Basel) on A Novel C-Type Lectin Receptor-Targeted α-Synuclein-Based Parkinson Vaccine We are pleased to announce that our newest paper in the journal Vaccines (Basel) is now published online. This study provides proof-of-concept for the efficacy of the ‘Win the Skin Immune System Trick’ (WISIT) vaccine technology platform, which induces […]