Kineto Lab Ltd. is an acknowledged expert in development of tailored, predictive screening
procedures employing primary patient tumors, xenograft assays and cell based preclinical screening procedures for anticancer agents.
Dissemination of malignant tumors (metastasis) is a cascade process consisting of growth of primary tumors, detachment of cells from the primary tumor and
local invasion of surrounding extracellular-matrix (ECM), intravasation, dissemination in the circulatory system, adhesion to the endothelial cells and vessel
local invasion of surrounding extracellular-matrix (ECM), intravasation, dissemination in the circulatory system, adhesion to the endothelial cells and vessel wall, extravasation and growth again in the secondary organs.
Tumor cell – ECM interaction has a pivotal role during these steps, which are mediated by adhesion receptors (integrins, non-integrin receptors and proteoglycans), motility factors and their receptors and enzymes responsible for digestion.
Steps of the metastatic process
Tumor growth, tumor cell detachment, tissue invasion
Interaction with blood elements
Arrest in the capillary system of the target organ
Establishment of metastatic foci